Sodium salt of pyroglutamic acid - Natural Moisturizing Factor in Human Skin

Sodium salt of pyroglutamic acid - Natural Moisturizing Factor in Human Skin

A number of documents describe the value of the pyroglutamic acid radical (also known as Sodium PCA) in the field of dermatology and cosmetics, and especially the fact that the sodium salt of pyroglutamic acid prevents dehydration of the skin and makes it soft, supple and elastic (J. Soc. Cosmet. Chem. (1984) 35(3) 171).

Sodium PCA is a naturally occurring component of human skin and a part of the "natural moisturizing factors" (NMF) that maintain a healthy epidermis. Sodium PCA is very hygroscopic , attracting moisture from the air. It imparts a moist feeling to hair and skin. Sodium PCA applied to the skin is absorbed to a limited extent. It is non-comedogenic, nonirritating to the eye and skin -- even at concentrations up to 50%, and does not contribute to phototoxicity or sensitization. It is rapidly biodegradable. Soluble in water and ethanol and insoluble in oils, it is used for its powerful humectant properties in many skin and hair care products including gels, creams, lotions, shampoos, conditioners, lipsticks and foundations.

One of the primary elements in keeping skin healthy is making sure the structure of the epidermis (outer layer of skin) is intact. That structure is defined and created by skin cells that are held together by the intercellular matrix. The intercellular matrix is the "glue" or "mortar" between skin cells that keep them together. It helps prevent individual skin cells from losing water and creates the smooth, non-flaky appearance of healthy, intact skin. The components that do this are often called natural moisturizing factors (NMFs) or ingredients that mimic the structure and function of healthy skin. While the oil and fat components of skin prevent evaporation and provide lubrication to the surface of skin, it is actually the intercellular matrix along with the skin's lipid content that gives skin a good deal of its surface texture and feel.

The intercellular matrix is the skin's first line of defense against water loss. When the lipid and NMF content of skin is reduced, we experience surface roughness, flaking, fine lines, and a tight, uncomfortable feeling. The longer the skin's surface layer (stratum corneum) is impaired, the less effective the skin's intercellular matrix becomes (Sources: Skin Research and Technology , August 2000, pages 128–134; and Dermatologic Therapy , Volume 17, Supplement 1, 2004, pages 43–48). Moreover, the skin's healing process is impaired. NMFs make up an expansive group of ingredients that include amino acids, ceramides, hyaluronic acid, cholesterol, fatty acids, triglycerides, phospholipids, glycosphingolipids, urea, linoleic acid, glycosaminoglycans, glycerin, mucopolysaccharide, and sodium PCA (pyrrolidone carboxylic acid).

All of the skin's supporting NMFs and lipids are present in the intercellular structure of the epidermis, both between skin cells and in the lipid content on the surface of skin. When any of these ingredients are used in skin-care products, they appear to help stabilize and maintain this complex intercellular-skin matrix. Although none of these very good NMFs and lipids can permanently affect or change skin, they are great at temporarily keeping depleted skin from feeling dry and uncomfortable. More important, all of these ingredients, and many more, can help support the intercellular area of the skin by keeping it intact. This support helps prevent surface irritation from penetrating deeper into the skin, works to keep bacteria out, and aids the skin's immune/healing system. Selecting moisturizers of any kind with NMFs (whether they are labeled as being antiaging, antiwrinkle, serums, lotions, or sunscreens) allows your skin to do its job of repairing and regenerating itself without the impedances brought on when skin is suffering from dryness and excess irritation (Sources: Clinical Geriatric Medicine , February 2002, pages 103–120; Progressive Lipid Research , January 2003, pages 1–36; Journal of the European Academy of Dermatology and Venereology , November 2002, pages 587–594; Contact Dermatitis , June 2002, pages 331–338; Journal of Investigative Dermatology , May 1996, pages 1096–1101; British Journal of Dermatology , November 1995, pages 679–685; Skin Pharmacology and Physiology , September–October 2004, pages 207–213; Free Radical Research , April 2002, pages 471–477; and Journal of Lipid Research , May 2002, pages 794–804).

BIO ACNE CARE
Gentle but effective acne treatment serum for pimples & acne cysts

The product is oil free and contains the following ingredients that act in concert to yield benefits that go beyond the sum of those of their specific parts:

a) our biological Helix Aspersa Müller Glycoconjugates with antioxidant, antimicrobial & skin regeneration properties to heal skin lesions within the follicles, control acne bacteria and prevent and get rid of acne scars;

b) the active extract of the bark of the Black willow ( Salix Nigra) tree to enhance cell renewal on the surface of the skin, unclog pores and reduce acneic skin flora (Propionibacterium acnes and Staphylococcus aureus). The actual content of willow (Salix Nigra) extract expressed as standarized salicylic acid is less than 0.5%. The Salix Nigra extract also provides natural B-hydroxy acid activity, without the skin irritation commonly associated with synthetic salicylic acid;

c) modified glucomannan (carbohydrate) -high molecular weight heterpolysaccharides made up of glucose and mannose derived from the Japanese Konjac tuber (root)- that reduce the surface tension of oil and facilitates its dispersion into droplets. These droplets get distributed evenly along the skin’s surface, minimizing their presence and oily feel;

d) Hyaluronic Acid a glycosaminoglycan (also present in the snail serum) to deeply moisturize the skin and restore the capacity of the skin to hold in moisture; and seaweed extracts that provide moisture and trace minerals necessary for the recovery of damaged skin cells; and sodium salt of pyroglutamic acid (naturally in human skin) moisturizer;

e) Japanese Licochalcone LR-15 from Licorice (Glycyrrhiza inflate) extract which clinicals (*) in Japan have shown that at very low concentration reduces undesired p. acnes and other acneic skin flora, is anti-irritating, anti-inflammatory and reduces sebum output.

Apply a thin layer twice a day on all the area affected with acne (whole face, chest or back) and then always use sun protection. If you are allergic to salycilic acid or to aspirin do not use the product and if you experience stinging or irritation (very unlikely) you must stop using the product and consult your physician.

Made in the USA. One Month Supply 50 grams = 1.76 oz

50 Grams in Airless Pump Bottle.
$59

(*) A New Dermatological Availability of the Flavonoid Fraction from Licorice Roots-Effect on Acne
Journal of Society Cosmetic Chemists Japan, VOL.37; NO.3; PAGE. 179-186(2003) Authors: Kambara Toshimitsu^a, Zhou Y, Kawashima Yoshihito^a, Kishida Naoko^a, Mizutani Kenji^a, Ikeda Takao^a, Kameyama Koichiro^b.

^a Research Center, Maruzen Pharmaceuticals Co., Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, 729-3102 Hiroshima, Japan. ^bAoyama Dermatological Clinic, dr@aoyamahihuka.com 5-1-3 Aoyama 8F Minato-ku Tokyo 107 Japan.

Abstract: Licochalcone-A, Polyol Soluble Licorice Extract P-U (now in the market as Licochalcone LR-15), prepared from the roots of Glycyrrhiza Inflata Batalin shows several activities such as inhibitory actions of testosterone 5 ALPHA-reductase, lipase and phospholipase A2, as well as androgen receptor antagonist, antimicrobial and SOD-like antioxidant actions, which relate to skin care, especially the suppression of acne formation and development. On basis of this evidence, a trial with acne patients was carried out and the efficacy of the extract was demonstrated clinically.

The Biological Skin Treatment Complex

The biological activity in human skin of a complex carbohydrate and protein compound, collected from a live creature that produces it to regenerate its skin and organs when damaged, enhances the flow of information that is necessary to repair skin damage in an orderly, orchestrated way, with scarless healing.

The serum in our BIOCUTIS products has the unique ability to dissolve damaged and abnormal collagen protein fibers in the dermis where they were created to repair damaged tissues that may result when inflammatory reactions destroy our own tissues in their quest to protect us from invading bacteria or foreign materials. It does so through the action of "digestive" enzymes that breakdown proteins into their amino acid components in coordination with the glycomolecules in the compound that help to discern damaged cells from normal functional cells.

When the liquid active biological ingredient is combined with lipids (Olive Oil derivatives) to make it into a cream and micro-crystals are added to the final product, it accomplishes results for old and rough acne scars through a polishing or microdermabrasion action, while also hydrating deeply, strengthening cell membranes and triggering an orderly regeneration of the skin matrix.

We collect the rich biological ingredient by using a humanely method without harming any of the little creatures.

BIO ACNE CARE - for moderate acne & acne cysts BIO ACNE CARE ™
A serum for moderate acne breakouts and for cystic acne. Contains the following ingredients acting in concert to yield benefits that go beyond the sum of those of the components:

a) Helix Aspersa Müller Glycoconjugates with antioxidant, antimicrobial & skin regeneration properties to heal skin lesions within the follicles, control acne bacteria and prevent and get rid of acne scars;

b) The active extract of the bark of the Black willow ( Salix Nigra) tree to enhance cell renewal on the surface of the skin, unclog pores and reduce acneic skin flora (Propionibacterium acnes and Staphylococcus aureus). The actual content of willow (Salix Nigra) extract expressed as standarized salicylic acid is less than 0.5%. The Salix Nigra extract also provides natural B-hydroxy acid activity, without the skin irritation commonly associated with synthetic salicylic acid;

c) Modified glucomannan (carbohydrate) -high molecular weight heterpolysaccharides made up of glucose and mannose derived from the Japanese Konjac tuber (root)- that reduce the surface tension of oil and facilitates its dispersion into droplets. These droplets get distributed evenly along the skin’s surface, minimizing their presence and oily feel;

e) Licochalcone LR-15 from Licorice (Glycyrrhiza inflate) extract which clinicals in Japan have shown that at very low concentration reduces undesired p. acnes and other acneic skin flora, is anti-irritating, anti-inflammatory and reduces sebum output.

50 Grams in Airless Pump Bottle.
: $59

BIOSKINCLEAR ™
An oil free moisturizer gel for acne, rosacea and facial scars. Heals lesions to the cells lining the hair follicles which is the root cause of inflammatory acne. Removes dead cells, unclogs sebum canals and dissolves scar tissues by enzymatic hydrolysis, without peeling. Promotes the proliferation of antimicrobials that control acne bacteria. Boosts reproduction of glycosaminoglycans, the molecules that retain water, thus truly moisturizing the skin from within. Tells the body it is being taken care off and can moderate an otherwise extreme inflammatory reaction that may end up destroying healthy skin cells and creating crater like scarring and not only the acne bacteria.

50 gram (1.76 oz) airless pump bottle $59
25% off for two or more.

BIOSKINEXFOL™
A home microdermabrasion cream with micro-crystals that breakdown hard, rough and old scar tissues, and allow for a deeper penetration of the natural skin regeneration complex that is in the cream.

120 gram (4 oz) jar = $89

BIOSKINCARE™ BIOSKINCARE ™
A natural skin care cream (without the micro-crystals) that triggers the regeneration of damaged cells and replenishes the lipid barrier of the skin while preventing and removing scars after healing of burns, injuries, wounds or surgery; Acne Scars; aberrant hypertrophic and keloid scars; keratois pilaris, actinic keratosis scales, dermatitis, dryness, cracked skin and all types of skin blemishes.

50 gram jar = $69.98
Two or more 20% discount

BIO SKIN REJUVENATION ™
Same cream base and enzymes as in BIOSKINCARE to "digest" or dissolve blemishes, speed skin turnover and tighten skin, and two added ingredients: one is a human growth factor peptide, derived from the melanocyte-stimulating-hormone. Blocks melanin synthesis, and reduces the formation of unwanted pigmentation, allowing control over skin tone and brown spots. The other is a natural plant extract that takes away dark pigmentation. Leaves skin bright and refreshed!

50 gram jar = $79